Start caring for your vaginal health with IMVEXXY, a small, softgel vaginal insert. Its revolutionary design treats moderate to severe painful sex, a symptom of vulvar and vaginal atrophy (VVA), after menopause.

Speak to an UpScript physician today to determine if IMVEXXY may be right for you.

$45.00 / Physician Visit Get Started

Please see Important Risk Information including Boxed Warning below.

Why Choose IMVEXXY?

  • Fast Acting

    In as fast as 2 weeks, IMVEXXY starts treating the actual problem behind vaginal pain and discomfort due to estrogen loss.*

  • Ultra-Low Dose

    The lowest dose vaginal estrogen out there. The ONLY bio-identical estrogen softgel insert that mimics the kind your body makes.**

  • Mess Free Administration

    inside and outside of your vagina with mess-free administration and no downtime.

  *Secondary endpoint from a 12-week clinical trial
**Bio-identical hormones are hormones that are structurally identical to the hormones your body produces naturally. It is not known if there is a difference in risks between synthetic hormones and bio-identical hormones.

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    Save on your prescription

    Find out how you can get IMVEXXY for as little as $35* with our savings card. You can text SAVE to 38745** or click the button below to get our savings coupon card.

    *Savings card offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please see Program Terms, Conditions, and Eligibility Criteria at Medicare cash paying and other cash paying patients may save through vitaCare℠ Prescription Services.

    **Message and data rates may apply. Reply HELP for help; reply STOP to cancel at any time. Up to 30 messages per month per request.


IMVEXXY (estradiol vaginal inserts) is a prescription medicine that contains an estrogen hormone in a vaginal insert. It is used after menopause to treat moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.


  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Report any unusual vaginal bleeding right away while you are using IMVEXXY. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone or with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogen-alone or with progestin may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone or with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • Talk to your doctor regularly about whether you still need treatment with IMVEXXY.


  • have unusual vaginal bleeding.
  • currently have or have had certain cancers.
  • currently have or have had blood clots.
  • had a stroke or heart attack.
  • currently have or have had liver problems.
  • have been diagnosed with a bleeding disorder.
  • are allergic to IMVEXXY or any of its ingredients.
  • think you may be pregnant.


Tell your healthcare provider about all of your medical conditions, including if you:

    • have any unusual vaginal bleeding.
    • have asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
    • are going to have surgery or will be on bed rest. You may need to stop using IMVEXXY.
    • are breast feeding.

Tell your healthcare provider about all the medicines you take. IMVEXXY may affect the way other medicines work, and other medicines may affect how IMVEXXY works.


  • headache
  • breast tenderness or pain
  • nausea and vomiting

The risk information provided here is not complete. To learn more, talk about IMVEXXY with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1–800-FDA-1088. You may also report side effects to TherapeuticsMD at 1-888-228-0150.

IVXY-20576 6/2021