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<div style="text-align:center; border-width:2px; border-style:solid; border-color:#2d2d2d; border-bottom: 0; padding:15px 10px 5px; color:#2d2d2d">WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA and BREAST CANCER See full prescribing information for complete boxed warning.</div>

IMPORTANT SAFETY INFORMATION

READ FULL &#8964

<div style="text-align:left;">
 <div style="text-align:left; border-width:2px; border-style:solid; border-color:black; padding: 5px; margin-bottom:5px;">

<div style="text-align:center;">
 
 WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA and BREAST CANCER
 
 
 See full prescribing information for complete boxed warning.
</div>
 
 Estrogen-Alone Therapy
 <ul class="list-d">
 <li class="fw-b padL25" style="margin-bottom: 5px;">There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens</li>
 <li class="fw-b padL25" style="margin-bottom: 5px;">The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT)</li>
 <li class="fw-b padL25" style="margin-bottom: 5px;">The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older</li>
 <li class="fw-b padL25" style="margin-bottom: 10px;">Do not use estrogen-alone therapy for the prevention of cardiovascular disease or dementia</li>
 </ul>
 Estrogen Plus Progestin Therapy
 <ul class="list-d">
 <li class="fw-b padL25" style="margin-bottom: 5px;">The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism (PE), and myocardial infarction (MI)</li>
 <li class="fw-b padL25" style="margin-bottom: 5px;">The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer</li>
 <li class="fw-b padL25" style="margin-bottom: 5px;">The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older</li>
 <li class="fw-b padL25" style="margin-bottom: 5px;">Do not use estrogen plus progestogen therapy for the prevention of cardiovascular disease or dementia</li>
 </ul>
 </div> 
 
 <h2>CONTRAINDICATIONS</h2>
 IMVEXXY (estradiol vaginal inserts) is contraindicated in women with any of the following conditions: undiagnosed abnormal genital bleeding; known, suspected, or history of breast cancer; known or suspected estrogen-dependent neoplasia; active DVT, PE, or history of these conditions; active arterial thromboembolic disease (for example stroke, MI) or a history of these conditions; known anaphylactic reaction, angioedema, or hypersensitivity to IMVEXXY; known liver impairment or disease; known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders. 
 
 <h2>WARNING AND PRECAUTIONS</h2>
 <ul class="list-d padL15 c-green-3">
 <li>Risks from systemic absorption. IMVEXXY is intended only for vaginal administration. Systemic absorption may occur with the use of IMVEXXY.</li>
 <li>Cardiovascular disorders, malignant neoplasms, and probable dementia. Please refer to Boxed Warning for endometrial cancer, cardiovascular disorders, probable dementia, and breast cancer.
 <ul>
 <li>The use of estrogen-alone and estrogen plus progestin therapy has been reported to result in an increase in abnormal mammograms requiring further evaluation.</li>
 <li>The WHI estrogen plus progestin substudy reported a statistically non-significant increased risk of ovarian cancer. A meta-analysis of 17 prospective and 35 retrospective epidemiology studies found that women who used hormonal therapy for menopausal symptoms had an increased risk for ovarian cancer. The exact duration of hormone therapy use associated with an increased risk of ovarian cancer, however, is unknown.</li>
 </ul>
 </li>
 <li>Other warnings include: gallbladder disease; severe hypercalcemia, loss of vision, elevated blood pressure, severe hypertriglyceridemia, cholestatic jaundice, fluid retention, and hypocalcemia in women with hypoparathyroidism.</li>
 <li>Estrogen therapy may exacerbate: hypothyroidism, endometriosis, hereditary angioedema, asthma, diabetes mellitus, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas, and should be used with caution in women with these conditions.
 <ul>
 <li>Women on thyroid replacement therapy should have their thyroid function monitored.</li>
 </ul>
 </li>
 </ul>
 
 <h2>ADVERSE REACTIONS</h2>
 <ul class="list-d padL15 c-green-3">
 <li>The most common adverse reaction with IMVEXXY (≥3%) was headache.</li>
 </ul>
 
 <h2>INDICATION</h2>
 IMVEXXY (estradiol vaginal inserts) is an estrogen indicated for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. 
 
 Please note that this information is not comprehensive. Please click <a class="c-green-2" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=104be9f2-a8f6-430e-9e01-2ee7cc1861f1" target="_blank" rel="noopener noreferrer">here</a> for the Full Prescribing Information, including BOXED WARNING.
</div>

IMPORTANT SAFETY INFORMATION

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Reduced vaginal pain in as little as 2 weeks.

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Available in both 4 mcg and 10 mcg.

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Designed to stay in place as it rapidly dissolves.

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Relieve moderate to severe painful sex during menopause with IMVEXXY: an easy-to-use softgel estradiol vaginal insert. Speak to an UpScript healthcare provider to learn if IMVEXXY is right for you. Eligible patients may pay as little as $25 per month.*

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Please see Important Safety Information, including BOXED WARNING. This website and the services offered here are owned and operated by UpScript Investments Holdings LLC. Any services provided and information shared through this website are subject to UpScript's legal terms and privacy policies. &nbsp;&nbsp;* This is not health insurance. Subject to change. Savings card offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please see Eligibility Criteria, Terms, Conditions, Restrictions, and Exclusions <a href="https://www.imvexxy.com/wp-content/uploads/2025/07/MAYNE_Imvexxy_Copay-Card_091125_NEW_5.pdf" target="_blank" rel="noopener noreferrer" style="color:blue;">here</a>.

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Relieve moderate to severe painful sex during and after menopause with IMVEXXY: an easy-to-use softgel estradiol vaginal insert. Speak to an UpScript healthcare provider to learn if IMVEXXY is right for you. Eligible patients may pay as little as $25 per month.*

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<div style="text-align:center; border-width:2px; border-style:solid; border-color:#2d2d2d; border-bottom: 0; padding-left: 5px; color:#2d2d2d">WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA and BREAST CANCER See full prescribing information for complete boxed warning.</div>

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